Residues (m g/kg) of alphacypermethrin in edible tissues of calves after application of a pour-on preparation - dose 0.15 g. The values are the ranges for five calves with the means in brackets. Muscle, fat and milk contained mainly a single component (muscle 85 %, fat 91 % and milk 97 % of the extract profile), which in each case had similar chromatographic properties to alphacypermethrin. The Committee recommends temporary MRLs for cattle, sheep and chickens of 100 m g/kg in muscle, liver and kidney, 500 m g/kg in fat, 25 m g/l for cows whole milk and 50 m g/kg for eggs expressed as parent drug. WL 85871 (ACYP, FASTAC). Alphacypermethrin is a pyrethroid insecticide consisting essentially of two of the four cis isomers comprising cypermethrin. A minor component (3 % of the profile) had identical chromatographic properties (HPLC) to 14C-3PBA (3-phenoxybenzoic acid). Figure 1. Confirmation was by combined gas chromatography mass spectrometry (GC-MS) monitoring the ions 207 and 209 in the negative ion chemical ionization mode. It is applied as a pour-on preparation for cattle and sheep, also as a dip for sheep and as a spray for poultry. The perirenal fat residues were 60-150 m g/kg after the first two weeks post-treatment, but then declined to about 10-20 m g/kg by day 28. Residues of alphacypermethrin (m g/kg) in sheep after treatment with either a pour-on application or a dip formulation of alphacypermethrin. are used in agricultural crops, mainly on Cypermethrin is an insecticide used both in agricultural and non-agricultural settings. Table 1. Sherren, A.J., (1988b). All muscle samples contained levels of radioactivity < 30 m g. High levels of total radioactivity were observed in bile (5212 m g equiv/l). It has a low aqueous solubility, in relatively volatile and, based on its chemical properties, is not expected to leach to groundwater. Product Name: Apparent Alpha-Cypermethrin 100 Duo Insecticide Other Names: A synthetic pyrethroid pesticide, Group 3A Insecticide. and Richardson, K.A., (1994). Documents related to EPA's review of this pesticide can be found in the following dockets: The results were submitted uncorrected for recovery. Thus all the values quoted are about 10-20 % on the low side of the actual corrected content. Two tentative values of 16 % in liver and 20 % in kidney were determined in one cow treated orally. The claimed LOQ were 1 m g/l for milk and 10 m g/kg for tissues. The authors have used the LOD at 5 m g/kg and not the LOQ of 20 m g/kg for quantification! The major route of excretion of radioactivity was via faeces, accounting for 34% of the total administered dose. Table 2. Alphacypermethrin is a highly active broad spectrum insecticide, effective by contact and ingestion against target pests. White, D.A., (1987). Cameron, D.A., Redgrave, V.A., MacDonald, I.A. The above is the search results for Chinese Cypermethrin, click for more recommended manufacturers & suppliers listings such as insecticide, pesticide, agricultural chemicals. The cis pair of isomers were in a single dose of 1.7-2.5 mg/kg body weight (BW) to 6 females and 6 males. The bound residues in the liver were treated with HCl and this liberated > 90 % of the radiolabel to yield metabolites similar to those in the free fraction (Croucher et al., 1985). Residue studies using unlabeled alphacypermethrin. The residues were measured in the albumen, yolk and whole egg and also in the yolks collected from five hens sacrificed at 14 days after dosing. Germany for the pesticide active substance cypermethrin are reported. In two of the studies there was evidence of persistence of residues in both subcutaneous fat and perirenal fat of calves. Alpha cypermethrin is a pyrethroid insecticide consisting essentially of two of the four cisisomers comprising cypermethrin. Genfarm Alpha Cypermethrin 250SC Insecticide For the control of certain insect pests, including redlegged earth mite on certain field crops and pastures and certain Insect pests on fruit and vegetable crops as indicated in the Directions for Use table. It is considered a serious marine pollutant. A study was carried out of the residues in eggs after a spray application of alphacypermethrin to hens (see Table 2 and Sogeval, 1992). The results were not corrected for recovery although the recoveries were determined in each study. The results are shown in Table 4. METHODS OF ANALYSIS FOR RESIDUES IN TISSUES, EGGS AND MILK. Alpha-cypermethrin is a broad-spectrum type II pyrethroid restricted use pesticide that is registered for use on soybeans, corn, vegetables, sugar beets, wheat, alfalfa and other minor crops. Fendona CS Controlled Release Insecticide. The studies are outlined in Table 1. Alpha-cypermethrin is the only non-selective knock down insecticide registered for the purpose of spraying insects in Blue Gum plantations. Residues of alphacypermethrin (m g/l) in whole bovine milk after application of three doses of a pour-on preparation. The conclusions were reached on the basis of the evaluation of the representative uses of alpha‐cypermethrin as an insecticide on cereals, winter oilseed rape, lettuces, leafy brassica and on cucumber and courgette in permanent glasshouses. The majority of the radioactivity was excreted within 48 hours followed by a persistent elimination over the remaining six days. Results suggest that this combination could be a potential insecticide resistance management tool for preventing malaria transmission in areas compromise … The LOQ varied between 10 and 30 m g/kg. Sort By. It is a non-systemic contact and residual insecticide with two to three times greater activity than regular cypermethrin. HRC report SLL 279/931913. Alphacypermethrin: Concentrations of Residues in Bovine Tissues. Determination of Residues of Alphacypermethrin in Milk. In another study residues at 7 days after a pour-on application were present in both perirenal fat (max. The results are shown in Table 7. Suitable methods for the specific analysis of alphacypermethrin in milk and the edible tissues were submitted. It is a racemic mixture of two isomers of Cypermethrin. Cypermethrin typically contains 20-40% alpha-cypermethrin. Residues as alphacypermethrin were measured in cattle, sheep and poultry after the topical application of unlabeled alphacypermethrin. Pest Management Science , 64 900-908. In one study with the pour-on treatment, residues in fat were not detectable within 7 days of dosing but in sheep which were dipped the residues were 40 m g/kg in fat at 7 and 14 days after dosing. Thus there is limited information on the ratio of alphacypermethrin to total residues in these tissues or in skin. The recovery of the method over a range of 5 to 20 m g/l alphacypermethrin was 95 to 105% and the limit of determination was claimed as 1 m g/l although no validation data other than for recoveries were provided. The 14C-metabolites in urine (72-96 h after initial dosing) were characterised by co-chromatography using HPLC and TLC. The total residues (measured as radioactivity) in the edible tissues were mostly below the LOQ (10-30 m g/kg). The results are shown in Table 3. specifications for alpha-cypermethrin alpha-cypermethrin information 6 alpha-cypermethrin long-lasting (incorporated into filaments) insecticidal net (october 2014) 7 part two evaluations of alpha-cypermethrin 2014.1 fao/who evaluation report on alpha-cypermethrin long-lasting (incorporated into filaments) insecticidal net 12 annex 1: references 13 View as Grid List. The limit of detection is 10 m g/kg although no validation data other than for recoveries were provided (SAMS 461-1). Further clean up was obtained by using a Cyano Bond Elut cartridge. Set Descending Direction. Find my closest branch Contact us Residues of Alphacypermethrin in Milk Following Topical Treatment of Cows with "Renegade" Pour-on in the UK. The Committee noted that alpha-cypermethrin comprises the two most toxicologically active isomers of cypermethrin. $27.50 As low as: $19.50 . Alpha-Cypermethrin; Alpha-Cypermethrin. In a poultry study, hens were treated with an alphacypermethrin spray and residues in eggs measured over a 14 day period. These figures are not significantly different from the radio counting estimates. Renal and subcutaneous fat samples from cows sacrificed at 7 and 14 days after treatment were also analysed for alphacypermethrin by GC with a LOQ of 10 m g/kg but only trace amounts were found. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. Sheep were treated with either a pour-on application or a dip formulation of alphacypermethrin (see study reference 4 in Table 2) and the residues in fat, skin and wool, measured in single sheep at 3, 7 and 14 days post-treatment. The results are shown in Table 5. - There are analytical methods available, however, evidence of validation is needed. In a further study (White, 1987) sheep were treated with a pour-on application at either 0.01 g/kg BW or twice this dose (see Table 2). The total residues (measured as radioactivity) in the edible tissues after the pour-on application were mostly below the LOQ (Redgrave et al., 1992). Mean levels rose to 7 m g/l as determined by radio counting and to 5 m g/l as determined by GC, by day 2. Two tentative values of 16 % in liver and 20% in kidney were determined as alphacypermethrin as a percentage of total residues in one cow treated orally. Search results for ALPHA - CYPERMETHRIN at Sigma-Aldrich. Whole milk or milk fat are suitable for monitoring milk and the yolk of eggs for monitoring eggs. Non-systemic with contact and stomach action. Two radiolabeled depletion studies in cattle (Redgrave et al., 1992; Cameron et al., 1993) were carried out, one with oral dosing and one using the pour-on application at the recommended dose (Morrison and Richardson, 1994). TITAN ALPHA-CYPERMETHRIN 250 SC INSECTICIDE • PAGE 4 OF 7 CROP INSECT PESTS STATE RATE WHP CRITICAL COMMENTS Lettuce Helicoverpa spp. High residues were found for at least two weeks in the skin after both treatments. Insecticide Pesticide Alpha-Cypermethrin 100g/L SC. Recoveries were given in the references and were mostly > 85 %. Chemical structure of eight cypermethrin stereoisomers. Over an eight day collection period 50-60% of the dose was excreted in the urine and 30-40% in the faeces. Residues were measured at 7, 14, 28 and 35 days after dosing. Cypermethrin, alpha-cypermethrin and zeta-cypermethrin are similar pyrethroid insecticides with the same basic chemical formula and molecular weight. Summary of Residues Trial in Hens and Eggs - Sogeval 1992. /alpha-Cypermethrin/ WHO International Programme on Chemical Safety; The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2009 p.26 (2010) (1997). Francis, W.P. Only in the subcutaneous fat of one cow slaughtered at 35 days post dosing was a residue measured at the LOQ of 30 m g/kg. Fastac® CS insecticide. Table 7. SAMS 461-1, (1988). Sheep which were dipped in a preparation of alphacypermethrin had higher residues in the fat, wool and skin than those receiving the pour-on application. The kidney extract contained at least nine metabolites with a broad range of polarities, one component (20% of the profile) had similar chromatographic properties to alphacypermethrin. Alpha cypermethrin is a pyrethroid insecticide consisting essentially of two of the four cis isomers comprising cypermethrin. * The range excludes one value of 24 which was claimed to be an outlier. After the application of the pour-on preparation no residues were detectable in the muscle and liver of young cattle and were < 30 m g/kg in kidney over the 14 day post dosing period. The studies carried out by the sponsor using the recommended preparations in cattle, sheep and poultry are summarised in Table 2. Total residues of radiolabeled alphacypermethrin in milk after a pour-on application. The methods were GC with electron capture detection followed by confirmation with GC-MS. Residues of alphacypermethrin (m g/kg) in sheep fat 7 days after treatment with pour-on applications of alphacypermethrin. Further information on the validation of the analytical methods; particulary data on the derivation of LOD and LOQs. Gas Liquid Chromatographic Method. Corresponding figures for cow 2 were both 20 m g/kg. The Joint FAO/WHO Meeting on Pesticide Residues (JMPR) had also evaluated cypermethrin and established an ADI of 0-0.05 mg/kg bw (JMPR, 1980, 1982). Residues of Alphacypermethrin (m g/kg) in calves and heifers after the application of 0.15 g in a pour-on preparation. 2 Item(s) Show. MOA: Sodium channel modulators, Pyrethroids, Pyrethrins, DDT Group: PYR CAS #: 67375308 Shaugnessy Code: 209600 Cypermethrin is toxic to the nervous system. For fat and muscle, a portion of the extract was partitioned with acetonitrile by using an Extrelut extraction cartridge. BASF Ag Products ALPHA-CYPERMETHRIN 7969-364. The metabolism of 14C-WL85871 after Repeated Oral Dosing in the Lactating Cow In-life Phase and Metabolite Profiling. Alphacypermethrin is a highly active broad spectrum insecticide, effective by contact and ingestion against target pests. The Committee requests the following information: 2. *Please select more than one item to compare Residues in bovine milk after the pour-on treatment reached peak values between days 2 and 5 after dosing and were all below the LOQ by day 21. and Gillis, N.A., (1993). Success (Spinetoram) is one potential alternative chemical. Extracts were further cleaned up by liquid-solid chromatography on a Florisil cartridge before analysis with GC-ECD. Levels fell to just on the limit of determination of 1 m g/l by day 7. Alpha-cypermethrin(CAS No.67375-30-8) is a non-systemic insecticide with contact and stomach action. Table 3. The results for the pour-on veterinary drug preparation are more applicable for the evaluations by JECFA. However, using topical application the total residues were below the LOQ in liver and kidney and, therefore, the sensitivity of the analytical methods could be considered in recommending an MRL for these tissues. 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